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There is no evidence-backed universal winner for killing both ants and spiders. For visible pests, choose a contact spray whose current label lists both pests and the exact place you plan to treat. For indoor ant trails, a labeled bait station may be a better fit—but bait stations target specific ant species and do not treat spiders. Always follow the product label; directions and permitted uses differ by product.
Choose by pest and treatment job
| Option | What it targets | Best fit | Important limits |
|---|---|---|---|
| Ant bait station | Ant species listed on that product’s label | Indoor ant trails or suspected nesting areas, where the label allows placement | Does not target spiders. Species exclusions and placement rules vary; keep stations inaccessible to children and pets. |
| Contact spray | Ants and spiders when both are listed on the label | Visible pests or specified spot and crack-and-crevice treatments | Permitted locations, application methods, and precautions are product-specific. Do not assume every spray is suitable for every surface or area. |
The available EPA labels do not provide head-to-head efficacy trials, so they do not establish which product works fastest, lasts longest, or controls the most pests.
When ant bait stations make sense
The EPA label for MGK Formula 31882 covers bait stations for specified ant species, but excludes fire, carpenter, harvester, and pharaoh ants. Its indoor directions call for placement near observed trails or suspected nesting areas, in places children and pets cannot access. The label also says to inspect stations periodically and replace them as needed. These directions apply to that product, not automatically to other baits. Read the MGK Formula 31882 label.
- Identify the ant as confidently as you can and check that the species appears on the label.
- Place the station only where the label permits and where children and pets cannot reach it.
- Do not spray insecticide over the station: the MGK label warns that this may make the bait repellent.
- Keep food and food-processing surfaces from being contaminated. The label notes that removing food and water sources helps bait acceptance.
When to use a spray labeled for both ants and spiders
A contact spray can address visible ants and spiders if the specific product label lists both pests and permits treatment at the intended site. For example, the EPA label for Insecticide 2656 RTU lists both pests for contact-spray uses and includes precautions for food, utensils, and food-handling surfaces. Check the Insecticide 2656 RTU label.
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#1 Best Overall
- TWIN PACK: Contains 2-17.5 ounce aerosol cans.
- FAST KNOCKDOWN: Kills listed insects on contact and keeps on killing up to 3 months on non-porous surfaces; excluding spiders, fleas, and carpenter, pharaoh and fire ants.
- KILLS INSECTS INDOORS: Controls ants (excluding harvester ants), cockroaches, spiders, fleas, silverfish, firebrats, crickets, Asian ladybeetles, carpet beetles, waterbugs, palmetto bugs and stink bugs indoors.
- KILLS INSECTS OUTDOORS: Kills ants, cockroaches, spiders, fleas, crickets, Asian ladybeetles, stink bugs, palmetto bugs and waterbugs outdoors.
- FRESH FLORAL SCENT: Controls insects while leaving behind a fresh floral scent.
The EPA master label for CS 101 Roach & Ant Spray, dated September 29, 2025, also lists ants and spiders for specified spot and crack-and-crevice treatments. It limits spot-treatment size and directs users to avoid contamination and runoff. Those limits are specific to that label; do not apply them as general spray directions. Review the CS 101 master label.
Check the label before treating
Use the label for the exact product in hand, not directions copied from another spray or bait. Confirm that it lists the pest, the intended indoor or outdoor location, and the treatment method. Follow its precautions for food, utensils, surfaces, children, pets, and application. The U.S. Environmental Protection Agency’s consumer guidance is direct: “Always read and follow the pesticide label’s instructions and safety warnings.” See EPA’s Do’s and Don’ts of Pest Control and its consumer pest-control resources.
Rank #2
- 2 spray bottles
- Kills spiders (including Black widow, brown recluse and hobo spiders), ants, cockroaches, crickets, scorpions, and other insects
- Kills on contact
- Can be used indoors and outdoors
When to get help identifying or treating the pest
If you cannot confidently identify the ant or spider, activity continues, or you would rather not apply pesticide yourself, contact a local pest-control professional. Check relevant local requirements and the provider’s qualifications before hiring.
Quick Recap
Best Value
- SAVE THE DAY: Kills on contact* and keeps killing up to 3 months**.
- KILLS INSECTS INDOORS AND OUTDOORS: Kills ants, cockroaches, spiders, fleas, crickets, Asian ladybeetles, palmetto bugs, stink bugs and other listed insects indoors and outdoors.
- FRESH FLORAL SCENT: Kills insects while leaving behind a fresh floral scent. Also available in Lemon, Crisp Linen and Fragrance-Free.
- NO OILY RESIDUE: Spray surface until damp; this product leaves no oily residue behind.
- IDEAL FOR SPOT TREATMENT: Use as a spot treatment indoors along and behind baseboards, around and beneath appliances, beneath and behind sinks and in other areas where insects are found.
Rank #4
- One 15 oz can of Raid Multi Insect Killer kills bugs on contact, including ants, Asian lady beetles, boxelder bugs, carpet beetles, crickets, firebrats, fleas, silverfish, flies, fruit flies, non-biting gnats, hornets, mosquitoes, roaches, and spiders (except brown recluse and black widow spiders)
- Raid Insect Killer works where crawling and flying bugs are causing issues, both indoors and outdoors
- This pest killer comes in an easy-to-use spray with an orange breeze scent and no lingering chemical odor for a pesticide that helps you work smarter, not harder, to fight bugs in your home
- Raid Bug Killer is ideal for use throughout your home to take care of your bug problem quickly
- Try other Raid bug spray and insect killer products like Raid Ant and Roach Killer for all of your pesticide and insecticide needs to keep your environment pest free
Rank #3
- WHERE TO USE INSECT SPRAY: Use this pest control spray indoors in kitchens and bathrooms or around doors and windows, and outdoors to the perimeter of foundations, patios, decks, garages or wherever insects are a recurring problem
- LONG-LASTING PROTECTION: This outdoor perimeter and indoor bug spray for homes creates a bug barrier that provides up to 12 month protection against ants, roaches and spiders when applied indoors on non-porous surfaces
- EASY-TO-USE APPLICATOR: This 1.33 gal. container of Ortho Home Defense Insect Killer for Indoor & Perimeter2 Ready-To-Use comes with a battery-powered Comfort Wand sprayer, which delivers a continuous spray for easy application
- INDOOR INSECT KILLER: Ortho Home Defense Insect Killer for Indoor & Perimeter2 is a bug killer spray that kills the toughest home-invading insects, including ants, cockroaches, spiders, fleas, ticks, scorpions, earwigs, silverfish, and more as listed
- WHEN TO USE: Apply this bug spray outdoors or indoors anytime as a preventative treatment or after you see evidence of insect activity
Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Amazon at the time of purchase will apply.
